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IGF-1 then activates intracellular pathways such as PI3K and mTOR, which regulate protein synthesis

These cells have a structural and regulatory function within the blood vessels and overlap in function and location with each other, sharing a wide range of subtypes with small phenotypic differences [10, 86,87,88]

The most common symptoms are mood swings ranging from emotional bursts to anger, reduced food intake, sometimes overeating, disturbed sleep, an inability to focus on work, a sense of guilt, hopelessness, and loneliness, which can lead to suicidal ideation if left untreated

However, these effects are not uniform and depend significantly on the type of nanoparticle, plant species, dosage, and mode of application

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[DOI] [PMC free article] [PubMed] [Google Scholar] 45.Li Y., Li W., Xu Z