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Elemene antitumor drugs development based on molecular compatibility theory and clinical application: a retrospective and prospective outlook

14 Essential antioxidants help counteract the effects of oxidative stress include glutathione peroxidase and super oxide dismutase (SOD), which bind to antioxidants and neutralize the negative effects

H TR TRAO I CHT To xon c th thc y qu trnh trao i cht ca mt ngi, khin h cm thy trn y nng lng hn

Pericyte dysfunction has been found to be associated with impaired brain perfusion [91, 92] and loss of BBB integrity [17, 91, 93]

In addition, many other mechanisms regulating ferroptosis have been revealed, such as the AMPK-mediated anti-ferroptotic effect of energy stress[97] and glutamate-cysteine ligase catalytic subunit (GCLC)-conferred protection against ferroptosis mediated by its contribution to maintaining glutamate homeostasis[86]

Xiayu Wu, Neng Cao, Michael Fenech, Xu Wang