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Ocular drug delivery: Role of degradable polymeric nanocarriers for ophthalmic application

Using reporter genes whose activity is driven by ARE half sites or by canonical AREs consisting of two such hexamers, the authors found that cooperativity between the LBDs enables transactivation from weaker, imperfect AREs and noted that direct AREs repeats do reinforce but are not required for AR dimerization

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In summary, future directions will likely include developing targeted pharmacologic treatments (perhaps inflammatory or neuromodulatory agents) for CRF

This allows it to support both neuronal health and cellular energy production in muscles and the brain
