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Upon its formation, S1P can be recycled to ceramide through S1P dephosphorylation, further degraded into hexadecenal and phosphoethanolamine, or released to the extracellular environment (234)

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Antioxidant and anti-inflammatory substances, such as D-mannose, icaritin (162) and Fer-1, inhibit ferroptosis in chondrocytes by regulating the GPX4 pathway, thereby slowing cartilage degeneration and decelerating the pathological process of OA (80, 163)

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