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Metabolic effects of L-Carnitine on prepubertal rat Sertoli cells

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Diets with higher levels of whole grains, such as brown rice, oats, and whole wheat products, and dietary fiber have been associated with the prevention of type 2 diabetes and cardiovascular disease, among other positive health outcomes

Accumulation of long-chain acyl-CoAs and other FA metabolites impairs insulin signaling and leads to the development of IR, a crucial pathophysiological factor for carbohydrate metabolism disorders consistent with the development of NAFLD (49)

Therefore, our findings suggest C10:2 could stimulate pulmonary vascular medial layer thickening and vascular stiffening by directly enhancing PASMCs proliferation and extracellular matrix remodeling, inhibiting PASMCs apoptosis, as well as inducing mitochondrial dysfunction