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(iii) increased drug uptake by tumor cells

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The following AR antagonists were tested: the peripherally restricted, i.e., which does not cross the bloodbrain barrier, 1 AR-selective antagonist atenolol (5.6 mol/kg), the not restricted metoprolol (8.8 mol/kg, 1 ) or CGP20712A (11 mol/kg, 1 ), the 2 AR-selective antagonist ICI-118551 (initial dose of 1 mol/kg, followed by 0.3 mol/kg/min throughout the experiment), or the peripherally restricted, 1+2 AR antagonist nadolol (8.5 mol/kg) (6)

[DOI] [PubMed] [Google Scholar] 13.Raza H., Robin M.A., Fang J.K., Avadhani N.G