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Altogether, these results suggest that inhibition of ferroptosis by targeting GSH metabolism is an important avenue for the development of new therapies for AD ( Oxidative Stress and Lipid Peroxidation Lipid peroxidation represents an important hallmark of AD (Sultana et al., 2013), which was also supported by the observed differential expression of ACSL3 and 4 in the course of the pathology (Tables 1, 2)

In comparison, tobramycin treatment was more effective for biofilms grown in the presence of the combination, showing significantly reduced biomass for both DFU-53 (25%32%) and UTI-62 (3%17%)

Nutrition and recovery amplify the effect

Notably, Grx2 is not sensitive to deactivation by electrophilic or oxidative stress

10.1002/mds.27874 53 HaqueM

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