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10.1021/bi002028t

Furthermore, co-mutant in vivo models of IDH2 R140Q and FLT3-ITD induced acute leukaemia and were essential for leukaemia maintenance ( Oxidative Phosphorylation It was originally assumed that mitochondrial respiration was impaired in cancer cells as they mainly rely on glycolysis for survival ( Normal HSCs maintain their quiescent state by reducing their mitochondrial respiration rate and relying on glycolysis ( Similar to quiescent HSCs, LSCs also have characteristically low levels of oxygen consumption and OXPHOS, but they still rely on this metabolic pathway for their survival ( + CD38 LSC population of primary AML samples ( Mitochondrial metabolism, the TCA cycle and OXPHOS are critical pathways to produce ATP molecules in LSCs and, under certain conditions, AML blasts

PMID: 40719051 Glia 2024 Feb;72(2):396-410

P.SymondsJ

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