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Sedlackova and Korolchuk, 2019)

Figure 2 Representative XIC chromatogram and low and high energy MS E spectra for CN + Parent (labeled RM03, m/z 352.1314 highlighted green in low energy precursor ion spectrum) following incubation of clozapine with human liver microsomes, stable label and unlabeled potassium cyanide, and NADPH

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Published 2021 Apr 15

Administration of oral GSH and L-cysteine have shown limited success in restoring GSH levels in the brain due to poor penetration through the bloodbrain barrier and first-pass metabolism by the liver, respectively

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