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SOM230: a novel somatostatin peptidomimetic with broad somatotropin release inhibiting factor (SRIF) receptor binding and a unique antisecretory profile

The Stress Axis and Cortisol Dysregulation Opiate withdrawal also disrupts the hypothalamic-pituitary-adrenal axis, the brains primary stress regulation system

Tonolo F, Folda A, Cesaro L, et al

Seventy-five patients with type 1 diabetes and various forms of autonomic neuropathy were enrolled in this study: 46 patients (mean age of 38.1 12.5 years) were treated with intravenous ALA (600 mg/day) for 10 days, then with oral ALA (600 mg film tablet/day) for 50 days, while 29 patients (mean age 40.2 9.3 years) served as the untreated control group

Side effects from nirogacestat were generally modest and included diarrhea and rash

Int J Biol Macromol 140:323329