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275 Further, a novel Wnt inhibitor, SM04690 were proved to effectively relieve the pain of severe symptomatic knee osteoarthritis (OA) and appeared safe and well tolerated through phase I/II clinical trial

Theoretical concerns about angiogenesis apply here as well

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This study identified that both treatment groups demonstrated a significantly reduced VAS score, with 85.7% and 77.6% of subjects decreasing in VAS score from baseline in the methylcobalamin plus acupuncture and methylcobalamin alone cohorts respectively

Lopez-Martinez MI, Miguel M, Garces-Rimon M