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Woodman CBJ, Collins SI, Young LS

This may be due to the fact that Mn 2+ ions are smaller and more tightly bound to polyP, making it easier to be wrapped in the cluster, while RER peptides are larger and have weaker interactions with polyP and can be dispersedly distributed in the area closer to the surface of the cluster (see details in Supplementary Figs

Hydrogendeuterium exchange For hydrogendeuterium exchange experiments, deuterated buffer was prepared by lyophilizing eIF2B assay buffer (20 mM HEPES, 200 mM KCl, 5 mM MgCl 2 and 1 mM TCEP pH 7.9) and resuspending it in deuterium oxide (Sigma-Aldrich, 151882)

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However, it is important to note that the absorption of orally administered NAC will be hindered when administered following the use of activated charcoal, which is commonly used to mitigate acetaminophen toxicity

doi: 10.3390/cancers13184570 164 ChengJWangXQiuLLiYMarraikiNElgorbanAMet al
