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But without a functional repair signal and enough blood flow to the area, some injuries don't heal they stabilize in a damaged state

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Although rats dosed with cyclosporin also develop renal surface changes that correspond to focal areas of collapsed proximal tubular regions with subcapsular fibrosis, degenerating tubular epithelium and thickening of the basement membrane, the chronic striped fibrosis and arteriolar lesions have not been reproduced experimentally

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While this route requires the peptide to cross the blood-brain barrier to reach CNS targets, the BBB is actually compromised in active MS lesions, which paradoxically may improve drug penetration at the sites where treatment is most needed

Semax (Met-Glu-His-Phe-Pro-Gly-Pro), a heptapeptide ACTH(4-7)PGP analogue, exerts direct CNS effects through melanocortin 4 receptor (MC4R) activation, BDNF-TrkB neurotrophin upregulation, glucocorticoid receptor (GR) modulation, and dopaminergic/serotonergic circuit normalisation