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Effects of particle size and surface modification on cellular uptake and biodistribution of polymeric nanoparticles for drug delivery

10:e8166

Disease states that increase shear stress in the endothelium could lead to increased expression of -globin through the activation of KLF2 and/or KLF4 and, consequently, contribute to the dysregulation of NO signaling by increasing -globin

The liver is the body's primary site for glutathione production and detoxification

As a result, methylation of promoter regions of critically important cell cycle regulatory genes, including but not limited to cyclin D2 and c-Myc, was reduced [178]

PMID: 41371167 J Control Release 2025 Dec 30:114591
