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For this reaction, the 5-methyl-THF, produced in the folate cycle by MTHFR, and vitamin B12 as a cofactor are required [11]
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Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus

Clin Sci 2012, 122: 591-597

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lvarez-Snchez N, Cruz-Chamorro I, Daz-Snchez M, Sarmiento-Soto H, Medrano-Campillo P, Martnez-Lpez A, et al
