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Probiotics and MicrobiomeModulating Approaches Given the role of microbial dysbiosis in periodontitis pathogenesis, probiotics have been investigated as adjunctive therapies aiming to restore a symbiotic oral microbiome and competitively inhibit pathogenic species [42, 43, 44, 45, 46, 47]

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4246 In IUA, ferroptosis exacerbates inflammation by releasing cytokines such as IL-6 and IL-8, which activate macrophages and stromal cells, thereby intensifying the inflammatory response

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[DOI] [PubMed] [Google Scholar] 143.Nickerson W.J., Falcone G., Strauss G

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and they enter the cytosol, contributing to the oxidative stress of the cell

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A proportion of the TNR molecules could also be found in lysosomes, pointing to some degree of degradation

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This unique form grants circRNAs greater stability and resistance to RNase R

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