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These results represented the first evidence of the existence of GRK-dependent mechanisms of desensitization of the 2C -AR in intact cells (Lembo et al., 1999)

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doi: 10.1093/emboj/18.17.4633 61 YangQGrahamTEModyNPreitnerFPeroniODZabolotnyJMet al
We assigned the carboxyl terminal (C-terminal) loop (C-loop) to face the cytosol and the amino terminal loop (N-loop) to face ER lumen according to the enriched positively charged residues at the C-terminal side 33 (Extended Data Fig

Sikiric et al., 2003) or muscle (Staresinic et al., 2006) or tendon (Staresinic et al., 2003
