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The high CD38 + NK cells and low CD38 + NK-like T cells from the synovial fluid of RA patients suppress Treg cell differentiation by stimulating mTOR signaling in CD4 + T cells ( + NKp44 + NK cells secret high level of IL-22 to promote the proliferation of fibroblast-like synoviocytes and lead to synovial hyperplasia, resulting in cartilage and bone destruction ( 3 Treatment of RA Traditional drug DMARDs including cyclophosphamide, sulfasalazine, methotrexate and NSAIDs are commonly used in the treatment of RA, although they can lead to some side effects and other functional impairments

B12 injections may help lower levels of homocysteine, an amino acid that, when elevated, can be a risk factor for heart disease and stroke

They found that carnitine administration was associated with a significant reduction in BMI, and waist and hip circumferences compared to placebo

Cancer-associated fibroblasts induce PDL1+ neutrophils through the IL6-STAT3 pathway that foster immune suppression in hepatocellular carcinoma

Mechanism mapping (Nature Communications, 2025) Identified the disordered p53 transactivation domain as the binding target, adding structural detail to the mechanism