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Splitting into twice-daily injections is reasonable at higher daily totals (e.g., 250 mcg AM + 250 mcg PM at a 500 mcg/day total)

VDR activation attenuate cisplatin induced AKI by inhibiting ferroptosis
Activates cell migration and angiogenesis pathways

Jan 2019;34(1):25-32

By considering the pharmacokinetic factors that determine the dose-concentration relationship, it is possible to individualize the dose regimen to achieve the target concentration
2017), all of which showed no difference in GSH levels between cases and controls
