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However, oxidative modification of Keap1 by ROS removes its inhibitory effects on Nrf2 and allows for Nrf2-mediated transcription of antioxidant related genes (Sekhar et al., 2010)

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It should be emphasized that while subgroup analyses can be suggestive, they do not give strong evidence that the drug actually helped to a specific subgroup

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Ozone therapy is also available as an intramuscular injection