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Glutamine is considered the rate-limiting factor in glutathione synthesis 58,59

This in turn may lead to GD, which can then result in pathological changes (see below)

1 Introduction Methylglyoxal (MG), a highly reactive byproduct of glycolysis, indiscriminately attacks critical biomolecules, inducing irreversible glycation modifications that trigger structural damage and functional disruption ( Host-derived MG and related aldehydes can restrict the survival of intracellular pathogens ( Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), must overcome this host-derived carbonyl stress to establish infection

doi: 10.1016/j.ijdevneu.2013.03.006 105 Snchez-GarridoMAGarca-GalianoDTena-SempereM

Given the core role of alpha-synuclein aggregation in PD, great attention has been paid to quantify alpha-synuclein using varied immunoassays including ELISA, xMAP or electrochemiluminescence
