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First, SELECT was not a primary prevention trial, and the data should not be extrapolated to all individuals with overweight and obesity to prevent major adverse CV events

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Treatment with B 12 injections is efficacious in restoring normal metabolism, alleviating symptoms, and reversing haematological and some neurological complications of deficiency.23 Anaemia usually resolves within six to eight weeks, but coexisting iron deficiency may be present and need oral iron supplementation7 and, in severe cases, parenteral iron infusion