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It is known that, in rat and human GLCL holoenzyme, cystamine completely inactivates rat GLCL activity by interaction with a thiol group that is thought to be at or near the l-glutamate-binding site in the wild enzyme [135,136,137,138] and also in a recombinant mutant (hGLCLC-C553G) where one cysteine group far from the active site was selectively inactivated [139]

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Carretero-Krug A, Montero-Bravo A, Morais-Moreno C, Puga AM, Samaniego-Vaesken L, Partearroyo T, et al

This potent serum harnesses the antioxidant benefits of glutathione and the

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Candida albicans exposures, sex specificity and cognitive deficits in schizophrenia and bipolar disorder