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In contrast, ser-1 mutants, which exhibited a longer baseline lifespan than wild-type animals, a finding also reported in the literature (Murakami & Murakami, 2007), showed a lifespan reduction upon LSD treatment

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However, only the SNRI duloxetine is recommended for treatment of CIPN in existing guidelines [6, 7, 44], based on modest medical evidence for efficacy in one randomized, double-blind, placebo-controlled CIPN-specific trial [45]