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Funding This work was supported by National Science Basic Research Program of Shaanxi and Basic Research Program of Xian Municipal Health Commission (Nos

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In addition, copper is also involved in the binding of HIF-1 to the hypoxia response element (HRE) sequence of target genes, which requires the copper molecular chaperone CCS, and activates EMT-related genes such as snail family transcriptional repressor 1 (SNAIL1), twist-related protein 1 (TWIST1), snail family transcriptional repressor 2 (SNAIL2), zinc finger E-box-binding homeobox 1 (ZEB1), zinc finger E-box-binding homeobox 2 (ZEB2), and E12/E47 (101)

5.2 Future directions Future research should address these shortcomings by exclusively using remogliflozin and using proven fibrosis scoring methods with specialized stains for fibrosis evaluation

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NAC reduces thrombotic complications by inhibiting the activity of plasminogen activator inhibitor-1, which is a procoagulant positively correlated with severe cases of COVID-19 [177, 178]