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Recommended Reading References Kuroda Y, et al

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10.1385/1-59259-413-1:273 [DOI] [PubMed] [Google Scholar] [236].Shivdasani R.A

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demonstrated that both murine and human leukemia models exhibit pronounced hypoxia, particularly within the bone marrow microenvironment, as confirmed by hypoxia markers and imaging

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MM patients who progressed after daratumumab treatment had elevated levels of the complement inhibitors CD55 and CD59, in agreement with the hypothesis that CDC represents a major mechanism of action for daratumumab and suggesting a mechanism of resistance to CDC-mediating antibodies

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