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Recommended Reading References Kuroda Y, et al

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demonstrated that both murine and human leukemia models exhibit pronounced hypoxia, particularly within the bone marrow microenvironment, as confirmed by hypoxia markers and imaging
MM patients who progressed after daratumumab treatment had elevated levels of the complement inhibitors CD55 and CD59, in agreement with the hypothesis that CDC represents a major mechanism of action for daratumumab and suggesting a mechanism of resistance to CDC-mediating antibodies

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