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doi: 10.3389/fnut.2025.1701661 Received 08 September 2025 Revised 10 November 2025 Accepted 04 December 2025 Published 05 January 2026 Volume 12 - 2025 Edited by Emanuele Micaglio, IRCCS San Donato Polyclinic, Italy Reviewed by Runzhe Xu, University of Texas Southwestern Medical Center, United States Husain Alkhaldy, King Khalid University, Saudi Arabia Updates Copyright 2026 de Carvalho, Akamine, Di Pietro, Frana, Oliveira and Lopes

Structural determinants of human proton-coupled folate transporter oligomerization: role of gxxxg motifs and identification of oligomeric interfaces at transmembrane domains 3 and 6