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The expression of SIRT1 and FoxO3a is significantly reduced in a spontaneous hypertensive rats (SHR) model and the NRK-52E cells exposed to Ang II

Rhoads JP, Major AS

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Keywords: MOTS-c, insulin resistance, obesity, muscle function, bone metabolism, immune regulation, aging 1

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GABA acts on GABAB receptors to inhibit microglia reactive responses to pro-inflammatory stimuli, such as lipopolysaccharide (LPS), which leads to inhibition of the relevant inflammatory pathways mediated by NF-B and p38MAP kinase, and reduces the release of IL-6, TNF [70]