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Effects of intracellular iron overload on cell death and identification of potent cell death inhibitors
Wetmore et al
These studies collectively highlight L-Carnitine as a promising therapeutic agent in the treatment of male infertility
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This NAD+ elevation activates sirtuins, particularly SIRT1 in adipocytes and hepatocytes, which deacetylates and activates numerous metabolic regulatory proteins including PGC-1, a master regulator of mitochondrial biogenesis, oxidative metabolism, and thermogenesis
