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However, insufficient efficacy in solid tumors and limited persistence in vivo remain key constraints to their broader application

Neuroscience 150 , 104120 (2007)

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Park J, Choi J, Cho I, Sheen YY (2022) Radiotherapy-induced oxidative stress and fibrosis in breast cancer are suppressed by vactosertib, a novel, orally bioavailable TGF-/ALK5 inhibitor

1 Conditions that cause increased destruction of Plts include autoimmune responses to antibodies against Plts, idiopathic TCP purpura (ITP), and hypersplenism