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Our screened acefylline derivatives possessed all therapeutic fragments according to a fragment-based drug discovery (FBDD) approach, such as an electron-rich zone, hydrophobic aromatic ring (aryl-binding site as the entrance cavity), and rigid hydrophobic aryl-binding site as the substrate cavity ( L -alaninamide), moclobemide (chloro-moiety containing morpholin-4-yl)ethyl]benzamide), istradefylline (dimethoxyphenyl moiety containing dihydro-1 H -purine-2,6-dione), lazabemide (aminoethyl moiety containing chloro-pyridine-2-carboxamide), chlorophenyl-based-nitrobenzothiazol-2-yl)semicarbazide, and bromophenyl-based-nitrothiazol-2-yl)semicarbazide) (Figure 3

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demonstrated that their synthesized Y-CDs not only have hydrophilic surfaces, but also exhibit more hydrophobic functions through in vitro studies

305331/2012-4 PQ/CNPq to MH

If sequencing Epithalon with Wolverine Blend: Complete the Epithalon cycle first, then start the Wolverine Blend cycle during the off period, or complete the Wolverine Blend cycle and schedule Epithalon for the off period

2004;65(suppl 4):510