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proposed a vascular normalization theory in which a judicious intensity of anti-angiogenic therapy could result in an equilibrium between anti-angiogenic and pro-angiogenic signals within the TMEvascular normalization statusand enable efficient delivery of oxygen, drugs, and anti-cancer immune cells into the tumor, rather than inducing excessive destruction of vessels and intratumoral hypoxia 35,36

One such example is tamoxifen, a selective estrogen receptor modulator (SERM), which prevents estrogen-driven cancer cell proliferation by binding to estrogen receptors and is particularly valuable for premenopausal women (213)

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doi: 10.1084/jem.20110367

The common inhalation anesthetic isoflurane induces caspase activation and increases amyloid beta-protein level in vivo

Mol Cancer Ther (2018) 17(6):1291302