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Description
The model includes detailed kinetic representation of intracellular metabolism linked within the cluster of tumor cells that simulates tumor spheroid systems
Therefore, the central area of the tumor presents a necrotic, hypoxic environment with an oxygen partial pressure as low as 728 mmHg, whereas the oxygen partial pressure of normal tissue is 4060 mmHg (West and Slevin, 2019)
In: Hatfield DL, Berry MJ, Gladyshev VN (eds) Selenium: Its Molecular Biology and Role in Human Health
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