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Quantification of phosphorylated Jak2 and tubulin expressions were performed by calculating the band density using 1D Digital Analysis Software (Kodak Digital ScienceTM, Eastman Kodak Company, Rochester, NY, USA)

Statistical analyses A descriptive analysis (mean, median and range) of the patients characteristics was performed for phase 1 and phase 2 of the DIVE-1 study

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Multivariate statistical analysis was performed using MetaboAnalyst v5.0 (Xia Lab, McGill University, Montreal, Quebec, Canada

The company's decision to advance both programs suggests confidence that the GLP-1/amylin dual pathway represents the future of obesity pharmacotherapy, with room for multiple formulations serving different patient preferences

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