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Neuroinflammation also plays a central role, with microglial activation and NF-B signaling implicated in elevated pro-inflammatory cytokines and depressive-like behaviors in mice [11,121]

In germ free mice, Klebsiella pneumoniae lung infection leads to a limited neutrophil mobilization favoring the pathogen growth (76)

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Acknowledgments The authors would like to thank the Changchun University of Chinese Medicine for supporting this research

Ascorbic acid supplementation improves postprandial glycaemic control and blood pressure in individuals with type 2 diabetes: findings of a randomized cross-over trial