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CoQ10 is another potent antioxidant that works alongside glutathione to protect against the premature signs of ageing

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Functional effects of a neuromelanin analogue on dopaminergic neurons in 3D cell culture

Hence, Nrf2 is consider to be a sensor of, and a protector, against the so called electrophilic stress.169,170 The action of Nrf2 depends on its accumulation in the nucleus, where it interacts with the antioxidant response element (ARE).171 This is a cis-acting enhancer sequence that contains the 5-TGAC-3 tetranucleotide present in the genes of enzymes associated with glutathione biosynthesis, redox proteins with active sulfhydryl moieties, drug-metabolizing enzymes and transporters