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These data in experimental models of AD with old 5XFAD mice could probably explain why the clinical efficacy of the monotherapeutic MEM approach is lost in moderate to severe memory deficits in advanced AD patients [37]

Our Guide for the Care and Use of Laboratory Animals meets United States regulations which are according to the Assessment and Accreditation of Laboratory Animal Care International (AAALAC) accreditation

An amount of 100 nmol/L CyRL-QN15 achieved a better effect than 100 mmol/L minoxidil [93]

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Melanin is classified into three types: namely, eumelanin, pheomelanin, and neuromelanin