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Combined curcumin and exercise intervention in hyperlipidemic rats downregulates pyroptosis genes (NLRP3, ASC (Apoptosis-associated speck-like protein containing a CARD), caspase-1) by inhibiting TLR4/MyD88/NF-B (Toll-like receptor 4/Myeloid differentiation factor 88/Nuclear factor kappa-B) signaling and reducing serum IL-1 (Ramos et al., 2016)

Boyle, and A

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Dose-Dependent Increase in Unconjugated Cinnamic Acid Concentration in Plasma Following Acute Consumption of Polyphenol Rich Curry in the Polyspice Study

Henry Sobo at Optimal Health Medical in Stamford, CT , with convenient telehealth access statewide .

In addition to altering receptor expression, selected probiotics modulate intracellular TLR signaling cascades, thereby suppressing downstream induction of inflammatory mediators