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The activated ZBP1 can interact with the RIP homotypic interaction motif (RHIM) domain of both RIPK1 and RIPK3 to mediate the NF-B activation and necroptotic cell death [100, 102, 104]

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J Obstet Gynaecol Can 30(8):671679 Mohamed-Hussein Z-A, Harun S (2009) Construction of a polycystic ovarian syndrome (PCOS) pathway based on the interactions of PCOS-related proteins retrieved from bibliomic data
Characterizing adult sleep behavior over 20 years-the Population-Based Doetinchem Cohort Study

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This impairment constitutes a fundamental barrier across multiple immunotherapy modalities, as it serves the critical link between the immune effector and its target antigen
