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These findings stress the necessity for future RCTs to adopt standardized intervention protocols, ensure preregistration with full methodological transparency, include biomarker-based subgroup analyses, and incorporate core outcome sets that allow for cross-study harmonization

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In fact, research has consistently demonstrated that individuals homozygous or heterozygous for ALDH2*2 have markedly higher acetaldehyde levels and reduced risk for AUD (122, 172, 178180), although they also have increased cancer risk (181, 182)

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