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[DOI] [PMC free article] [PubMed] [Google Scholar] 55.Korge P., Calmettes G., Weiss J

While classical gene mutations are region-limited, epimutations often occur early in cancer development and have a genome-wide impact, boosting on the one hand the expression of cell survival genes or proto-oncogenes and deactivating on the other hand tumor suppressor genes (TSGs), DNA repair mechanisms as well as cell division brakes, thus leading to carcinogenesis (Esteller, 2008

After incubation, the media was aspirated from each well, and DMSO was added to dissolve the formazan crystals formed in the viable cells

Experiments with specific inhibitors showed that the activity ratio of the three transporters EAAT1: EAAT2: EAAT3 found at the abluminal membrane was 1:3:6, respectively

And my response was pretty simple: Holy cow
Leyden J, Stephens T, Finkey MB, Appa Y, Barkovic S
