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[DOI] [PMC free article] [PubMed] [Google Scholar] 35.Pitt JM, Marabelle A, Eggermont A, Soria JC, Kroemer G, Zitvogel L

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Conclusions and perspective Almost 90 years after its initial discovery, NAD + is emerging as a central metabolite in the ageing field, and NAD + level decline is becoming an established feature of several age-associated diseases

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Moreover, addition of CD38i to etomoxir treatment reinvigorated the IFN- production in noncontrollers, indicating that FAO blockade is reversible after additional treatment with CD38i, which may relate to increased levels of NAD + , which boost glycolysis (Figure 7K)