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The presence of these lesions in the cortex and hippocampus after examination of the brain in imaging studies has been associated with progressive amnesic dementia and impairment of several cognitive functions ( An important factor that aggravates the accumulation of A and NFTs, and therefore contributes to the onset and progression of AD, is oxidative stress ( i.e

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The combination of ferroptosis inducers with TMZ produces synergistic killing effects, and GPX4 inhibitors such as RSL3 can significantly amplify the cytotoxic effects of TMZ