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Many nuclear receptors retain full ligand-dependent transcriptional activity by binding to coactivators containing short leucine-rich LxxLL motifs (where x can be any amino acid) known as nuclear receptor (NR) boxes 78

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To investigate such DM-mediated changes in erectile tissue, we monitored dynamic alterations in the composition of endothelial cells, smooth muscle cells, nerves, and pericytes within the corpus cavernosum

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