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Vitamin B12 absorption begins in the mouth but mainly occurs in the stomach and small intestine with the help of intrinsic factor, a protein that helps your body absorb B12. Weight loss surgery results in anatomical changes, such as a smaller stomach, reduced stomach acidity, and changes to the small intestine, that can lead to vitamin B12 malabsorption and decreased intrinsic factor secretion

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In the next step of the experiment, the researchers removed the beta(3)-adrenergic receptors in order to see the resulting effect on weight loss