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Studies carry out in isolated nuclei obtained from the liver demonstrated GSH role in the modulation of the thiol/disulfide redox status of nuclear proteins and in the control of chromatin compacting and decondensation [53]

Taking the advantages of these important roles in human health, manganese-based compounds and materials have been considered as a kind of potential candidates for novel diagnosis strategy, vaccine and drug development

Mice received once-daily sham injections with isotonic saline from 3 days before study start and were randomized to treatments on the basis of body weight at the day of study start

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Thus, p21-driven senescence is protective in acute settings but deleterious when persistent, underscoring its role as a context-dependent regulator rather than a simple tumor suppressor