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Thus, various tumors, including glioma, secondary glioblastoma, and acute myeloid leukemia (AML), harboring heterozygous point mutations in the active sites of IDH1/2 show dramatic increases in the R-2-HG levels 111,113,114,115

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Due to the physiological activities of the Heyi, Xila, and Badagan themselves, as well as the influence of peoples diet, daily life, seasons, and other factors, the Heyi, Xila, and Badagan have the possibility of excessive growth or depletion, leading to a loss of coordination