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For the targeted acquisition of MS/MS spectra (parallel reaction monitoring) for the ubiquitin chainderived signature peptides, the Orbitrap Fusion LUMOS instrument was operated in targeted MS/MS mode using the Xcalibur software

The regulatory approval process for MSC therapies is still evolving, with the FDA and other regulatory bodies working to establish clear guidelines for the clinical application of MSC-based products

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In the original 2015 Cell Metabolism paper, MOTS-c activated AMPK, improved insulin sensitivity in diet-induced obese mice, and reduced age-related insulin resistance in older animals [2]