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Subsequent studies have found that high levels of IGF-1 (10 nm) are protective, whereas cells treated with 0.3 nm IGF-I succumbed to cellular apoptosis (41, 72, 73)

Streptozotocin produces oxidative stress, inflammation and decreases BDNF concentrations to induce apoptosis of RIN5F cells and type 2 diabetes mellitus in Wistar rats

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