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The most consistent finding: researchers who dose MOTS-c in the morning during fasted states report more pronounced shifts in substrate utilizationmeasured via respiratory exchange ratio (RER)than those administering it post-meal

Rocio T Martinez-Nunez, et al

Clinical trials show no effect of 3 agonists on activating lipolysis and increasing energy expenditure (227, 228)

The answer depends on the person, some people benefit from a weekly injection, while others may only need one every two to four weeks

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